In the last 10 years, we have taken the basic research performed in mice one step further and several clinical trials have been performed or are now ongoing. Clinical proof of concept has been obtained in different indications such as smoking cessation, allergy, asthma, hypertension, cancer and influenza virus infection. A vaccine against Alzheimer`s disease, CAD106, is currently tested by Novartis in phase III studies. We are currently working towards clinical testing of a novel vaccines against allergy and on precision medicine vaccines against cancer.